Cardiac P2X4 Receptor Overexpression Can Prolong Survival After Infarction and Rescue Ischemic Heart Failure
نویسندگان
چکیده
منابع مشابه
A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy.
The P2X4 purinergic receptor (P2X4R) is a ligand-gated ion channel. Its activation by extracellular ATP results in Ca2+ influx. Transgenic cardiac overexpression of the human P2X4 receptor showed an in vitro phenotype of enhanced basal contractility. The objective here was to determine the in vivo cardiac physiological role of this receptor. Specifically, we tested the hypothesis that this rece...
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Purinergic1 receptors were initially conceived to describe the likely existence of membrane receptors responding to adenosine triphosphate (ATP) (P2 receptors) or its breakdown product adenosine (P1 receptors) in causing nonadrenergic, noncholinergic relaxation of gut smooth muscle.1 Cloning of these receptors has yielded insights into their properties and signaling mechanisms, allowing classif...
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We have demonstrated using immunoprecipitation and immunostaining a novel physical association of the P2X4 receptor (P2X4R), a ligand-gated ion channel, with the cardioprotective, calcium-dependent enzyme endothelial nitric oxide synthase (eNOS). Treatment of murine ventricular myocytes with the P2XR agonist 2-methylthioATP (2-meSATP) to induce a current (mainly Na(+)) increased the formation o...
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Objectives: The primary purpose of this study was to determine the methods and means of prevention and treatment of coronary artery disease. In this study, we used a new regimen on heart rate and functional capacity of patients after myocardial infarction. This study also determines the effect of a new regimen on these factors. Methods: The cross sectional study was designed to assess the clin...
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Evidence is accumulating to support the presence of P2X purinergic receptors in the heart. However, the biological role of this receptor remains to be defined. The objectives here were to determine the role of cardiac P2X receptors in modulating the progression of post-myocardial infarction ischemic heart failure and to investigate the underlying mechanism. The P2X4 receptor (P2X4R) is an impor...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.1130.12